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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Tectochrysin, Cetuximab
Phytochemical Name Tectochrysin (PubChem CID: 5281954 )
Anticancer drug Name Cetuximab (PubChem CID: / )
Structure of
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 480
Ref_1
Pair Name Tectochrysin, Cetuximab
Disease Info [ICD-11: 2B90] Colon cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Cleavage CASP3 hsa836
Down-regulation Expression CD40 hsa958
Down-regulation Expression CXCL8 hsa3576
Down-regulation Phosphorylation EGFR hsa1956
Down-regulation Expression FOS hsa2353
Down-regulation Phosphorylation IKBKE hsa9641
Down-regulation Activity JUN hsa3725
Down-regulation Activity NFKB1 hsa4790
Down-regulation Expression PTGS2 hsa5743
Down-regulation Expression RELA hsa5970
In Vitro Model HCT 116 Colon carcinoma Homo sapiens (Human) CVCL_0291
SW480 Colon adenocarcinoma Homo sapiens (Human) CVCL_0546
Result Our results indicate that combined therapy with lower concentration of cetuximab and tectochrysin could significantly enhance the cancer cell growth inhibitory effect through the inhibition of EGFR signaling.
03. Reference
No. Title Href
1 Synergistic inhibitory effect of cetuximab and tectochrysin on human colon cancer cell growth via inhibition of EGFR signal. Arch Pharm Res. 2016 May;39(5):721-9. doi: 10.1007/s12272-016-0735-7. Click
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